中井 雄治
食事をすると、からだがなんとなく温かくなった気がします。これは気のせいではなく、実際に体温が少し上昇します。この現象は「特異動的作用」とか「食事誘導性熱産生」と呼ばれており、からだが食べた物に応答していることを示すわかりやすい事例の一つです。
特異動的作用だけでなく、からだは摂取した食品に対し様々な応答を示します。特定保健用食品、いわゆるトクホに代表される機能性食品は、こうしたからだの応答を引き起こす食品の生理機能に注目したものです。私たちは食品摂取時の体の応答を遺伝子発現の変化として捉え、網羅的に解析する「ニュートリゲノミクス」の手法を用いて、食品が生理機能を発揮するメカニズムを調べています。
また、私たちのグループでは、新たな食品機能性の探索にショウジョウバエを用いています。ショウジョウバエは飼育スペースが少なくて済み、寿命が約2ヶ月と短いので、短期間に多くの条件で飼育することが可能です。必要な飼料も少量でコスト的にも有利です。ショウジョウバエは遺伝学的手法が確立されており、様々な変異体を利用することが可能です。現在、がんをごく初期の段階で予防する機能や、加齢に伴う認知・運動機能の低下を抑制する機能を評価する系などを用いて、食品の機能性探索を行っています。
主な研究テーマ
農林水産物中の機能性成分が生理機能を発揮するメカニズムを探る
高リン食摂取ラットモデルを用いた高リンシグナルの解析
略歴
1996年3月 東京大学大学院農学生命科学研究科応用生命化学専攻博士課程修了、博士（農学）
1996年4月-1997年12月 国立衛生試験所（現国立医薬品食品衛生研究所）ポスドク
1997年12月-2000年7月 理化学研究所ポスドク
2000年8月-2005年2月 金沢大学薬学部助手
2005年3月-2007年3月 東京大学大学院農学生命科学研究科アグリバイオインフォマティクス人材養成ユニット特任助教授
2007年4月-2009年2月 東京大学大学院農学生命科学研究科アグリバイオインフォマティクス人材養成ユニット特任准教授
2009年2月-2014年2月 東京大学大学院農学生命科学研究科ILSI Japan寄付講座 機能性食品ゲノミクス特任准教授
2014年3月-2018年3月 弘前大学食料科学研究所教授
2018年4月 弘前大学地域戦略研究所食料科学研究部門教授（改組のため）、現在に至る
研究業績
原著論文
Li, J-S., Suzui N., Nakai, Y., Yin, Y-G., Ishii, S., Fujimaki, S., Kawachi, N., Rai, H., Matsumoto, T., Sato-Izawa, K., Ohkama-Ohtsu, N., Nakamura, S-I. (2021) “Shoot base responds to root-applied glutathione and functions as a critical region to inhibit cadmium translocation from the roots to shoots in oilseed rape (Brassica napus)” Plant Sci., 305,110822.
Zhang, M., Nagaosa, K., Nakai, Y., Yasugi, T., Kushihiki, M., Rahmatika, D., Sato, M., Shiratsuchi, A., and Nakanishi, Y. (2020) “Role for phagocytosis in the prevention of neoplastic transformation in Drosophila.” Genes Cells., 25, 675-684.
Takagi, T., Hayashi, R., Nakai, Y., Okada, S., Miyashita, R., Yamada, M., Mihara, Y., Mizushima, K., Morita, M., Uchiyama, K., Naito, Y., and Itoh, Y. (2020) “Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity in Obese Japanese men—A Randomized, Double-Blind Trial.” Nutrients, 12, 2342.
Yokoyama, I., Nakai, Y., Suzuki, Y., Ohata, M., Komiya, Y., Nagasao, J., and Arihara, K. (2020) “DMHF (2,5-dimethyl-4-hydroxy-3(2H)-furanone), a volatile food component generated by the Maillard reaction, promotes appetite and changes gene expression in the rat brain through inhalation.” J. Food Sci., 85, 1338-1343.
Yamaguchi, M., Nishida, T., Sato, Y., Nakai, Y., and Kashiwakura, I. (2020) “Identification of Radiation-Dose-Dependent Expressive Genes in Individuals Exposed to External Ionizing Radiation.” Radiat. Res., 193, 274-285.
Toyoda, T., Iida, I., Ishijima, T., Abe, K., Okada, S., and Nakai, Y. (2020) “A maple syrup extract alleviates liver injury in type 2 diabetic model mice.” Nutr. Res., 73, 97-101.
Nguyen, H. T. M., Akanuma, G., Tu, H. T. M., Nakai, Y., Kimura, K., Yamamoto, K., and Inaoka, T. (2020)”Ribosome reconstruction during recovery from high hydrostatic pressure-induced injury in Bacillus subtilis.” Appl. Environ. Microb., 86, e01640-19.
Nakamura, S-I. Wongkaew, A., Nakai, Y., Rai, H., and Ohkama-Ohtsu, N. (2019) “Foliar-applied glutathione activates zinc transport from roots to shoots in oilseed rape.” Plant Sci., 283, 424-434.
Yanagida, K., Igarashi, H., Yasuda, D., Kobayashi, D., Ohto-Nakanisi, T., Akahoshi, N., Sekiba, A., Toyoda, T., Ishijima, T., Nakai, Y., Shojima, N., Kubota, N., Abe, K., Kadowaki, T., Ishii, S., and Shimizu, T. (2018) “The Gα12/13-coupled receptor LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity.” JCI Insight, 3, e97293.
Miura, S., Yamaguchi, M., Yoshino, H., Nakai, Y., and Kashiwakura, I. (2019) “Dose-Dependent Increase of Nrf2 Target Gene Expression in Mice Exposed to Ionizing Radiation.” Radiat. Res., 191,176-188.
Shimazu, K., Fukumitsu, S., Ishijima, T., Toyoda, T., Nakai, Y., Abe, K., Aida, K., Okada, S., and Hino, A. (2019) “The anti-arthritis effect of olive-derived maslinic acid in mice is due to its promotion of tissue formation and its anti-inflammatory effects.” Mol. Nutr. Food Res., 63, e1800543.
Segawa, S., Kondo, Y., Nakai, Y., Iizuka, A., Kaneko, S., Yokosawa, M., Furuyama, K., Tsuboi, H., Goto, D., Matsumoto, I., and Sumida, T. (2018) “Placenta specific-8 suppresses IL-18 production through regulation of autophagy and is associated with Adult Still’s disease.” J. Immunol., 201, 3534-3545.
Tatsumi, D., Hayashi, Y., Endo, M., Kobayashi, H., Yoshikawa, T., Kiso, K., Kanno, S., Nakai, Y., Maeda, I., Mochizuki, K., Tachibana, M., Koseki, H., Okuda, A., Yasui, A., Kono, T., and Matsui, Y. (2018) “DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells.” PLOS ONE, 13, e0205969.
Izuchi, R., Ishijima, T., Okada, S., Abe, K. and Nakai, Y. (2018) “Hepatic fatty acid biosynthesis in KK-Ay mice is modulated by administration of persimmon peel extract: a DNA microarray study” Food Sci. Nutr., 6, 1657-1663.
Yoshinaga, K., Nakai, Y., Izumi, H., Nagaosa, K., Ishijima, T., Nakano, T., and Abe, K. (2018) “Oral administration of edible seaweed Undaria pinnatifida (wakame) modifies glucose and lipid metabolism in rats: a DNA microarray analysis.” Mol. Nutr. Food Res., 62, e1700828.
Kuroki, S., Nakai, Y., Maeda, R., Okashita, N., Akiyoshi, M., Yamaguchi, Y., Kitano, S., Miyachi, H., Nakato, R., Ichiyanagi, K., Shirahige, K., Kimura, H., Shinkai, Y., and Tachibana, M. (2018) “Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.” Stem Cell Rep., 10, 1340-1354.
Matsumoto, K., Nakai, Y., Hoshino, M., Yamazaki, K., Takioto, Y., Takadera, S., Nakagawa, T., Nishimura, R., and Kusakabe, M. (2017) “Comprehensive DNA microarray expression profiles of tumors in tenascin-C-knockout mice.” Biosci. Biotechnol. Biochem., 81, 1926-1936.
Li, M., Kanda, Y., Ashihara, T., Sasano, T., Nakai, Y., Kodama, M., Hayashi, E., Sekino, Y., Furukawa, T., and Kurokawa, J. (2017) “Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.” J. Pharmcol. Sci., 134, 75-85.
Nonaka, S., Ando, Y., Kanetani, T., Hoshi, C., Nakai, Y., Nainu, F., Nagaosa, K., Shiratsuchi, A., and Nakanishi, Y.(2017) “Signaling Pathway for Phagocyte Priming upon Encounter with Apoptotic Cells.” J. Biol. Chem., 292, 8059-8072.
Tometsuka, C., Koyama, Y-I., Ishijima, T., Toyoda, T., Teranishi, M., Takehana, K., Abe, K., and Nakai, Y. (2017) “Collagen Peptide Ingestion Alters Lipid Metabolism–Related Gene Expression and the Unfolded Protein Response in Mouse Liver.” Br. J. Nutr., 117, 1-11.
Inoue, J., Ihara, Y., Tsukamoto, D., Yasumoto, K., Hashidume, T., Kamimura, K., Nakai, Y., Hirano, S., Shimizu, M., Kominami, R., and Sato R., (2016) “Identification of BCL11B as a regulator of adipogenesis.” Sci. Rep., 6, 32750.
Hashidume, T., Kato, A.,Tanaka, T., Miyoshi, S., Itoh, N., Nakata, R., Inoue, H., Oikawa, A., Nakai, Y., Shimizu, M., Inoue, J., and Sato R. (2016) “Single ingestion of soy β-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects.” Sci. Rep., 6, 28183.
Chun, S., Bamba, T., Suyama, T., Ishijima, T., Fukusaki, E., Abe, K., and Nakai, Y. (2016) “A High Phosphorus Diet Affects Lipid Metabolism in Rat Liver: A DNA Microarray Analysis.” PLoS ONE, 11, e0155386.
Maruyama, R., Shimizu, M., Ishijima, T., Nakai, Y., Inoue, J., and Sato, R. (2016) “Searching for novel ATF4 target genes in human hepatoma cells by microarray analysis.” Biosci. Biotechnol. Biochem., 80, 1149-1154.
Kanouchi, H., Kakimoto, T., Nakano, H., Suzuki, M., Nakai, Y., Shiozaki, K., Akikoka, K., Otomaru, K., Nagano, M. and Matsumoto, M. (2016) “The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice.” PLoS ONE, 11, e0150796.
Matsuura-Hachiya, Y., Nakai, Y., Arai, K., Abe, K., and Nishiyama, T. (2015) “Recovery of extracellular matrix components by enalapril maleate during the repair process of ultraviolet B- induced wrinkles in mouse skin.”Biochem. Biophys. Rep., 4, 180-186.
Yoshida, K., Ushida, Y., Ishijima, T., Suganuma, H., Inakuma, T., Yajima, N., Abe, K., and Nakai, Y. (2015) “Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury.” World J. Gastroenterol., 21, 10091-10103.
Oba, C., Ito, K., Ichikawa, S., Morifuji, M., Nakai, Y., Ishijima, T., Abe, K., and Kawahata, K. (2015) “Effect of orally administered collagen hydrolysate on gene expression profiles in mouse skin: a DNA microarray analysis.”Physiol. Genomics, 47, 355-363.
Kong, Q., Nakai, Y., Kuroda, N., Shiratsuchi, A., Nagaosa, K., and Nakanishi, Y. (2015) “Peptidoglycan recognition protein-triggered induction of Escherichia coli gene in Drosophila melanogaster.” J. Biochem., 157, 507-517.
Kikuchi, Y., Toyoda, T., Ishijima, T., Abe, K., Nakai, Y., and Fukudome S-I. (2014) “Oral administration of the AYA strain of Lactobacillus plantarum modulates expression of immunity-related genes in the murine Peyer’s patch: a DNA microarray analysis.” Biosci. Biotechnol. Biochem., 78, 1935-1938.
Horiba, T., Katsukawa, M., Abe, K., and Nakai, Y. (2014) “Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells.” Biosci. Biotechnol. Biochem., 78, 1923-1929.
Jaroensanti, N., Yoon JM., Nakai, Y., Shirai, I., Otani, M., Park, SH., Hayashi, KI., Nakajima, M., and Asami, T. (2014) “Does the brassinosteroid signal pathway in photomorphogenesis overlap with the gravitropic response caused by auxin?” Biosci. Biotechnol. Biochem., 78, 1839-1849.
Tsuboi, H., Nakai, Y., Iizuka, M., Asashima, H., Hagiya, C., Tsuzuki, S., Hirota, T., Miki, H., Hagiwara, S., Kondo, Y., Tanaka, A., Moriyama, M., Matsumoto, I., Nakamura, S., Yoshihara, T., Abe, K., and Sumida, T. (2014) “DNA microarray analysis of labial salivary glands in IgG4-related disease. Comparison with Sjögren’s syndrome.”Arthritis Rheumatol., 66, 2892-2899.
Honda, S., Kawamoto, S., Tanaka, H., Kishida, H., Kitagawa, M., Nakai, Y., Abe, K., and Hirata, D. (2014) “Administered chrysanthemum flower oil attenuates hyperuricemia: mechanism of action as revealed by DNA microarray analysis” Biosci. Biotechnol. Biochem., 78, 655-661.
Taniguchi, M., Fujiwara, K., Nakai, Y., Ozaki, T., Koshikawa, N., Toshio, K., Kataba, M., Oguni, A., Matsuda, H., Yoshida, Y., Tokuhashi, Y., Fukuda, N., Ueno, T., Soma, M., Nagase, H. (2014) “Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole-imidazole polyamide, which targets an E-box motif.” FEBS Open Bio., 4, 328-34
Kanda, A., Ishijima, T., Shinozaki, F., Nakayama, K., Fukasawa, T., Nakai, Y., Abe, K., Kawahata, K. and Ikegami, S. (2014) “Post-exercise impact of ingested whey protein hydrolysate on gene expression profiles in rat skeletal muscle: activation of extracellular signal-regulated kinase 1/2 and hypoxia-inducible factor-1α.” Br. J. Nutr., 111, 2067-2078.
Fukui, Y., Sasaki, E., Fuke, N., Nakai, Y., Ishijima, T., Abe, K. and Yajima, N. (2014) “Sequential gene expression profiling in the mouse spleen during 14 d feeding with Lactobacillus brevis KB290.” Br. J. Nutr., 111, 1957-1966.
Kuroki, S., Akiyoshi, M., Tokura, M., Miyachi, H., Nakai, Y., Kimura, H., Shinkai, Y. and Tachibana, M. (2013) “JMJD1C, a JmjC Domain-Containing Protein, Is Required for Long-Term Maintenance of Male Germ Cells in Mice.” Biol. Reprod., 89:93
Kamei, A., Watanabe, Y., Kondo, K., Okada, S., Shinozaki, F., Ishijima, T., Nakai, Y., Kondo, T., Arai, S. and Abe, K. (2013) “Influence of a Short-Term Iron-Deficient Diet on Hepatic Gene Expression Profiles in Rats.” PLoS ONE,8, e65372.
Fukui, Y., Sasaki, E., Fuke, N., Nakai, Y., Ishijima, T., Abe, K. and Yajima, N. (2013) “Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis.” Br. J. Nutr., 110, 1617-1629
Watanabe, S., Katsube, T., Hattori, H., Sato, H., Ishijima, T., Nakai, Y., Abe, K. and Sonomoto, K. (2013) “Effect of Lactobacillus brevis 119-2 isolated from Tsuda kabu red turnips on cholesterol levels in cholesterol-administered rats.” J. Biosci. Bioeng., 116, 45-51.
Huang, L., Nakai, Y., Kuwahara, I., and Matsumoto, K. (2012) “PRAS40 is a functionally critical target for EWS repression in Ewing’s sarcoma.” Cancer Res. 72, 1260-1269.
Suyama, T., Okada, S., Ishijima, T., Iida, K., Abe, K., and Nakai, Y. (2012) “High Phosphorus Diet-induced Changes in NaPi-IIb Phosphate Transporter Expression in the Rat Kidney: DNA Microarray Analysis.” PLoS ONE, 7, e29483.
Watanabe, Y., Kamei, A., Shinozaki, F., Ishijima, T., Iida, K., Nakai, Y., Arai, S., and Abe, K. (2011) “Ingested Maple Syrup Evokes a Possible Liver-protecting Effect —Physiologic and Genomic Investigations with Rats.”Biosci. Biotechnol. Biochem., 75, 2408-2410.
Shibata, M., Ishimatsu-Tsuji, Y., Yokoo, M., Nakai, Y., Abe, K., and Muta-Takada, K. (2011) “Effect of oral intake of winged bean extract on a skin lichenification model: evaluation by microarray analysis.” BioFactors 37, 421-428
Nakai, Y., Sato, B., Ushiama, S., Okada, S., Abe, K., and Arai, S. (2011) “Hepatic Oxidoreduction-related Genes Are Upregulated by Administration of Hydrogen-saturated Drinking Water.” Biosci. Biotechnol. Biochem., 75, 774-776.
Izuchi, R., Nakai, Y., Takahashi, H., Ushiama, S., Okada, S., Misaka, T., and Abe, K. (2011) “Hepatic gene expression of the insulin signaling pathway is altered by administration of persimmon peel extract: a DNA microarray study using type 2 diabetic Goto-Kakizaki rats.” J. Agric. Food Chem., 59, 3320-3329.
Nakamura, A., Fujiwara, S., Ishijima, T., Okada, S., Nakai, Y., Matsumoto, I., Misaka, T., and Abe, K. (2010) “Neuron differentiation-related genes are upregulated in the hypothalamus of odorant-inhaling rats subjected to acute restraint stress.” J. Agric. Food Chem. 58, 7922-7929.
Ushiama, S., Nakamura, T., Ishijima, T., Misaka, T., Abe, K., and Nakai, Y. (2010) “Hepatic Genes for Immunoproteasome Are Upregulated by Refeeding after Fasting in Rat.” Biosci. Biotechnol. Biochem. 74, 1320-1323.
Kamei, A., Watanabe, Y., Ishijima, T., Uehara, M., Arai, S., Kato, H., Nakai, Y., and Abe, K. (2010) “Dietary iron deficient anemia induces a variety of metabolic changes and even apoptosis in rat liver: a DNA microarray study.”Physiol. Genomics 42, 149-156.
Horiba, T., Nishimura, I., Nakai, Y., Abe, K., and Sato, R. (2010) “Naringenin chalcone improves adipocyte functions by enhancing adiponectin production.” Mol. Cell. Endocrinol. 323, 208-214.
Ishimoto, Y., Nakai, Y., Satsu, H., Totsuka, M., and Shimizu, M. (2010) “Transient up-regulation of immunity- and apoptosis-related genes in Caco-2 cellscocultured with THP-1 cells evaluated by a DNA microarray analysis.”Biosci. Biotechnol. Biochem. 74, 437-439.
Aizawa, K., Matsumoto, M., Inakuma, T., Ishijima, T., Nakai, Y., Abe, K., Amano, F. (2009) “Administration of Tomato and Paprika Beverages Modifies Hepatic Glucose and Lipid Metabolism in Mice: a DNA Microarray Analysis.” J. Agric. Food Chem. 57, 10964-10971.
Kadota, K., Nakai, Y., and Shimizu, K. (2009) “Ranking differentially expressed genes from Affymetrix gene expression data: methods with reproducibility, sensitivity, and specificity.” Algorithms Mol. Biol. 4: 7.
Motoyama, K., Nakai, Y., Miyashita, T., YFukui, Y., Morita, M., Sanmiya, K., Sakakibara, H., Matsumoto, I., Abe, K., Yakabe, T., Yajima, N., and Shimoi, K. (2009) “Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice.” Physiol. Genomics 37, 79-87.
K Kadota, K., Nakai, Y., and Shimizu, K. (2008) “A weighted average difference method for detecting differentially expressed genes from microarray data.” Algorithms Mol. Biol. 3: 8.
Shimizu-Ibuka, A., Nakai, Y., Nakamori, K., Morita, Y., Nakajima, K-I., Kadota, K., Watanabe, H., Okubo, S., Terada, T., Asakura, T., Misaka, T., and Abe, K. (2008) “Biochemical and Genomic Analysis of Neoculin Compared to Monocot Mannose-Binding Lectins.” J. Agric. Food Chem. 56, 5338-5344.
Nakai, Y., Hashida, H., Kadota, K., Minami, M., Shimizu, K., Matsumoto, I., Kato, H., and Abe, K., (2008) “Up-regulation of Genes Related to the Ubiquitin-Proteasome System in the Brown Adipose Tissue of 24-h-fasted Rats.” Biosci. Biotechnol. Biochem. 72, 139-148.
Kadota, K., Araki, R., Nakai, Y., and Abe, M. (2007) “GOGOT: a method for the identification of differentially expressed fragments from cDNA-AFLP data.” Algorithms Mol. Biol. 2: 5.
Aoki, F., Honda, S., Kishida, H., Kitano, M., Arai, N., Tanaka, H., Yokota, S., Nakagawa, K., Asakura, T., Nakai, Y., and Mae, T. (2007) “Licorice flavonoids suppress abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice.” Biosci. Biotechnol. Biochem. 71, 206-214.
Kadota, K., Ye, J., Nakai, Y., Terada, T., and Shimizu, K. (2006) “ROKU: a novel method for identification of tissue-specific genes.” BMC Bioinformatics 7: 294.
Nakai, Y., Shiratsuchi, A., Manaka, J., Nakayama, H., Takio, K., Zhang, J-T., Suganuma, T., and Nakanishi, Y. (2005) “Externalization and recognition by macrophages of large subunit of eukaryotic translation initiation factor 3 in apoptotic cells.” Exp. Cell Res. 309, 137-148.
Nakai, Y., Nomura, Y., Sato, T., Shiratsuchi, A., and Nakanishi, Y. (2005) “Isolation of a Drosophila gene coding for a protein containing a novel phosphatidylserine-binding motif.” J. Biochem. 137, 593-599.
Ishii, H., Mori, T., Shiratsuchi, A., Nakai, Y., Shimada, Y., Ohno-Iwashita, Y., and Nakanishi Y. (2005) “Distinct localization of lipid rafts and externalized phosphatidylserine at the surface of apoptotic cells.” Biochem. Biophys. Res. Commun. 327, 94-99.
Manaka, J., Kuraishi, T., Shiratsuchi A., Nakai, Y., Higashida, H., Henson, P. and Nakanishi Y. (2004) “Draper-mediated and phosphatidylserine-independent phagocytosis of apoptotic cells by Drosophila hemocytes/macrophages.” J. Biol. Chem. 279, 48466-48476
Nakai, Y., Irie, S., and Sato T-A. (2000) “Identification of IκBα as a Substrate of Fas-associated Phosphatase-1.”Eur. J. Biochem. 267, 7170-717.
Aso, Y., Yoshioka, S., Nakai, Y., and Kojima S. (1999) “Thermally Controlled Protein Release from Gelatin-Dextran Hydrogels.” Radiat. Phys. Chem. 55,179-183
Yoshioka, S., Aso, Y., Nakai, Y., and Kojima S. (1998) “Effect of High Molecular Movility of Poly(vinyl alcohol) on Protein Stability of Lyophilized γ-Globulin Formulations.” J. Pharm. Sci. 87, 147-151
Nakai, Y., Yoshioka, S., Aso, Y., and Kojima S. (1998) “Solid-State Rehydration-Induced Recovery of Bilirubin Oxidase Activity in Lyophilized Formulations Reduced during Freeze-Drying.” Chem. Pharm. Bull. 46, 1031-1033
Nakai, Y., Nishimura, T., Shimizu, M., and Arai S. (1995) “Effects of Freezing on the Proteolysis of Beef during Storage at 4 ℃.” Biosci. Biotechnol. Biochem. 59, 2255-2258
Ohoka, Y., Nakai, Y., Mukai, M., and Iwata M. (1993) “Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage.” Biochem. Biophys. Res. Com. 197, 916-921
Iwata, M., Mukai, M., Nakai, Y., and Iseki R. (1992) “Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes.” J. Immunol. 149, 3302-3308
連絡先
中井 雄治（なかい ゆうじ）
yunakaiアットマークhirosaki-u.ac.jp
